DR. A.S. SOIN

Dr. A. S. SOIN Hepatobiliary and Liver Transplant Surgeon

Dr. A. S. SOIN Hepatobiliary and Liver Transplant Surgeon
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Chief Hepatobiliary and Liver Transplant Surgeon Chairman, Medanta Institute of Liver Transplantation and Regenerative Medicine Medanta-The Medicity, Gurgaon (Delhi-NCR),India

Dr A S Soin is recognized all over the world over for his pioneering work in establishing liver transplantation in India. From 2001 to mid-2010, he established a big liver transplant centre at Sir Gangaram Hospital. However, in June 2010, he moved with his entire team to Medanta-The Medicity, Gurgaon (Delhi-NCR). Medanta at the current bed strength of 925 (and soon to be 1500) is one of the largest and the most modern tertiary care hospitals in the country, where Dr. Soin has established a 150-bedded (including 36 Liver ICU beds) dedicated Liver Treatment facility, carrying out 250 liver transplants and hundreds of complex liver and biliary tract surgeries every year.

Dr. A. S. Soin is senior surgeon of Liver Transplantation in India and performed more than 1500 liver transplants in India. Doctor Soin is the initial surgical training was at the All India Institute of Medical Sciences (AIIMS), New Delhi. He spent 11 years there gaining his MBBS and MS Degrees followed by specialist experience in Liver and Gastrointestinal Surgery.Dr A S. Soin has work Experience in Liver Transplantaion.And performed more than 1500.

Medanta Liver Institute is a first of its kind dedicated Institute in Asia and one of the few in the world, which combines state-of the art facilities for Living donor, Cadaveric donor, pediatric and adult liver transplantation along with a large research programme for stem cell and liver cell transplantation. These are cutting edge technologies that can potentially treat liver failure without transplant.

Dr Soin has performed more than 2000 living donor liver transplants in India, which is the highest in the country, and the second highest in the world. He and his team currently perform 22-25 live donor liver transplants every month with 95% success - results which are at par with the world's best centres. Apart from referrals from all over the country, he handles cases from the rest of South Asia, The Middle East and Africa.

Besides running their own highly successful programme, he and his team are also responsible for training most of the remaining liver transplant teams in India and neighbouring countries that have recently started performing this procedure. In disseminating expertise countrywide and beyond, building confidence in the procedure among patients and their referring physicians, and in moving it from experimental status to a highly successful life-saving procedure, he has in the true sense, pioneered the development of this speciality in India and the subcontinent in the last 15 years.

In his extensive experience of 21 years as a Liver Transplant Surgeon and Hepatobiliary surgeon, he has performed more than 1500 liver transplants and more than 12000 other complex liver, gall bladder and bile duct surgeries.

Dr Soin serves on the committees of all the important National and International Societies, as well as the National Advisory Board in Liver Transplantation. He is a regular Faculty member and speaker (often the only one from India) at most world fora in Liver Transplantation such as ILTS, AASLD, APDW, IHPBA, IASGO, APASL, Asian Living Donor Liver Transplant Group, Asia Pacific Organ Transplant Forum etc.

Summary of Academic Career of Dr. A. S. Soin

Doctor Soin's initial surgical training was at the All India Institute of Medical Sciences (AIIMS), New Delhi. He spent 11 years there gaining his MBBS and MS degrees followed by specialist experience in Liver and Gastrointestinal Surgery, during which he published a research thesis on Portal Hypertensive Gastropathy.

He then obtained FRCS degrees from both Glasgow and Edinburgh in the UK, following which he trained and worked at two of the world’s most renowned centers (University of Cambridge 5 years, University of Birmingham 1 year) for Liver and Biliary Surgery, and Liver, Kidney, Small Bowel and Pancreas transplantation for 6 years. He was one of the first few surgeons in the UK to qualify for and obtain an Intercollegiate FRCS in Transplant Surgery.

In addition to performing hundreds of transplants, he was Surgical Tutor for the University of Cambridge, and Faculty for 2 of the Royal Colleges in Surgery. At Cambridge, he also conducted pioneering research in transplantation. More than 110 of his original research papers and book contributions have been published / in international / national journals and books.

He was a Visiting Fellow at the Kyoto University Hospital in 1997 and Asan Medical Centre, Seoul, in 2000. He was Visiting Faculty at the Ege University, Izmir, Turkey in 2004, and Istanbul in 2006 and 2007. These centres are among the world’s most renowned for living donor liver transplantation.

In the beginning of 1998, he gave up the opportunity of a Faculty post at University of Cambridge and chose to return to India to establish a centre of excellence in liver transplantation in his own coutry.

Milestones achieved in transplantation in India

In Liver Transplantation in India, I have the following FIRSTS TO MY CREDIT as the Chief Surgeon assisted by the other members of the team:


  • First successful cadaveric liver transplant in India - 1998
  • First successful left lobe liver transplant in India - 1999
  • First successful right lobe liver transplant in India - 2000
  • First successful long distance cadaveric Liver Transplant in which the liver was flown in from Chennai and transplanted in Delhi - 1999.
  • First successful transplant at Apollo Hospital - 1998
  • First successful transplant at Sir Ganga Ram Hospital - 2001
  • First successful combined liver and kidney transplant in India - 1999
  • First successful reduced cadaveric liver transplant in a child - 2003
  • First successful transplant in India on a Pakistani patient - 2004
  • First bloodless liver transplant in India - 2005
  • First successful emergency liver transplant on a patient transported to Delhi by air ambulance in deep coma – 2005
  • India’s youngest ever recipient (11 months) to receive successful liver transplant - 2008.
  • India’s oldest recipient (70 years) of liver transplant – successful transplant in 2006.
  • World’s first combined liver and kidney transplant in the same patient (with primary hyperoxaluria) using organs from two different live donors - 2007
  • India’s first successful dual lobe liver transplant (double liver transplant in the same patient) – 2007
  • India’s first successful re-transplant (on a patient a year and a half after the first) – 2008
  • India’s first and world’s youngest Domino liver transplant – 2009
  • India’s smallest liver transplant recipient – (6 kg) – 2009
  • India’s first (and the world’s first reported) successful swap liver transplant – 2009
  • World’s first chain of three simultaneous liver transplants (combined domino and swap) 2012
  • India’s first successful ABO-incompatible liver transplants 2012
  • India’s first surgeon to complete 1000 liver transplants and 100 liver transplants in children 2012 and first to complete 1500 liver transplants in 2013, and 2000 in 2015.
  • India’s first successful Intestinal Transplant – 2013
  • India’s youngest and smallest ever recipient (4 months, 4 kg) to receive successful liver transplant - 2013.
Awards/Academic Achievements

National Award

1. Awarded Padma Shri by the President of India in 2010 for pioneering the development of Liver Transplantation in India.

2. Awarded the RD Birla Outstanding Clinician of the Year Award for the year 2010

3. Awarded the Zee TV - Swasth Bharat Samman Award for pioneering Liver Transplantation, 2011

4. Medical Statesman of the Year – e-MEDINEWS AWARDS, 2012

5. MSOSA Award for Excellence, 2014

6. Awarded the RD Birla Outstanding Clinician of the Year Award for the year 2010

7. Awarded the Zee TV - Swasth Bharat Samman Award for pioneering Liver Transplantation, 2011

8. Medical Statesman of the Year – e-MEDINEWS AWARDS, 2012


Other Achievements and Awards

1. X standard (O-level) 1979: Ranked 15th in India in the National Borad Examination.

2. XII standard, (A-level) 1981: Ranked 17th in India in the National Board Exam.

3. National Talent Scholarship in 1981 for 9 years.

4. Best Student in Surgery medal in 1985 at AIIMS, New Delhi.

5. Best Postgraduate Student in Surgery medal in 1989 at AIIMS, New Delhi.

6. Ranked first in All India selection exam for Senior Resident in Surgery at AIIMS, New Delhi, 1990

7. Awarded the Zee TV - Swasth Bharat Samman Award for pioneering Liver Transplantation, 2011

8. Medical Statesman of the Year – e-MEDINEWS AWARDS, 2012

9. Best Postgraduate Student in Surgery medal in 1989 at AIIMS, New Delhi.

10. Ranked first in All India selection exam for Senior Resident in Surgery at AIIMS, New Delhi, 1990.

11. Awraded British Transplantation Society Bursary (1994) for research presentation at the Kyoto World Transplant Congress. 8. Awarded British Transplantation Society Bursary (1997) for Visiting Fellowship at the Kyoto Liver Transplant Unit.

12. Awarded research grant from the Royal College of Surgeons of Edinburgh 1996.

13. DMA Distinguished Services Award on July 1, 2005 for outstanding contribution to and pioneering achievements in Liver Transplantation in India.

14. 2008 Medindia Oration and Medindia Award for pioneering contribution in Liver Transplantation, Chennai, 2008.

15. DMA Award for excellence in Organ Transplantation 2010.


Publications

1. Soin AS, Nundy S. Alimantary duplications and diverticulae. South Indian Surgical Clinics 1988; 2: 132-8.

2. Gupta S, Soin AS, Gupta S, Sikora S, Sharma LK. Delayed sepsis after Ivalon Sponge Rectopexy. An unsual case. Aust NZ J Surg 1991; 61: 469-71.

3. Sharma LK, Gupta S, Soin AS, Sikora, Kapoor VK. Generalised peritonitis in India – the tropical spectrum. Jap J Surg 1991; 21: 272-7.

4. FUmana JP, Soin AS, Harrison JD et al. Liver Transplantation (LT) in patient sover 60: rational use of a scarce resource? Gut 1993; 34(suppl): S21.

5. Soin AS, Gunson BK, Mirza DF et al. Treatment of persistent acute rejection in hepatic allografts in an era of FK 506 (Abstract) In: The abstract book of the Combined Dutch and British Transplantation Society meeting, 11-12 October, 1993.

6. Soin AS, Gupta S, Kochupillai N, Sharma LK. Primary Hyperparathyroidism – an Indian study. Indian Journal of Cancer 1994; 31: 72-7.

7. Soin AS, Rasmussen A, Friend P et al. Cyclosporin levels in the early posttransplant period – predictive of chronic rejection in liver transplantation? Transplantation 1995; 59: 1119-23.

8. Soin AS, Jamieson NV. Native hepatic artery pseudoaneurysm after liver transplantation: an unusual presentation with biliary leak. European Journal of Vascular and Endovascular Surgery 1995; 10: 376-9.

9. Soin AS, Jamieson NV. Living related liver transplantation. National Medical Journal of India 1995; 8: 126-7.

10. Tokat Y, Soin AS, Saxena R et al. Posttransplant pronlems requiring regrafting: an analysis of 72 patients with 96 liver retransplants. Transplantation Proceedings 1995; 27: 1264-5.

11. Saxena R, Soin AS, Tokat Y, Rasmussen A, Jamieson NV, Calne R. Relationship between patterns of hepatobiliary vascular supply and biliary complications in liver transplantation. Transplantation Proceedings 1995; 27: 1199-1200.

12. Soin AS, Rasmussen A, Jamieson NV et al. Cyclosporin levels in th early posttransplant period- predictive chronic rejection in liver transplantation? Transplantation Proceedings 1995; 27:1129.

13. Soin AS, Friend PJ, Rasmussen A et al. Donor arterial variations in liver transplantation: Management and outcome 527 consecutive grafts. The British Journal of Surgery 1996; 83: 637-41.

14. Soin AS, Friend PJ. A simple modification to improve technical success rate of small bowel transplantation in rats. Transplantation Proceedings 1996; 28(6): 2722.

15. Soin AS. Immunosuppression small and large bowel transplantation. Challenges in Immunosuppression No. 2, Jan 1996.

16. Soin AS, Friend PJ, Noble-Jamieson G et al. Successful transplantation of size-mismatched liver grafts in children by delayed primary closure of the abdominal wall. The British Journal of Surgery 1996; 83: 1532-6.

17. Soin AS, Jamieson NV. The lessons learnt from the randomized clinical trials of tacrolimus. National Medical Journal of India, 1996; 9: 224-6.

18. Saxena R, Soin AS, Tokat Y, Rasmussen A. The ischaemic basis of biliary complications in Liver Transplantation – an anatomico-clinical study. Indian Journal of Gastroenterology 1996; 15: V1.

19. Soin AS. UK doctors opposed to contractual obligation to report underperforming colleagues. National Medical Journal of India, March-April 1996.

20. Soin AS. Specialist Registrar Training Scheme in the UK. National Medical Journal of India. May-June 1996.

21. Soin AS. The right to die. National Medical Journal of India. September-October 1996.

22. Soin AS. The current status of xenotransplantation in the U.K. National Medical Journal of India. March-April 1997.

23. Evans PC, Soin AS, Ramsay LA, Toogood G, Wight DGD, Alexander GJM. IgA antibodies to 39 kD and 94 kD bile duct antigens anticipate chronic rejection. Hepatology (suppl) 1997.

24. Soin AS, Chavez R, Chavez G, Jamieson NV, White DJG, Friend PJ. Role of complement in rat small bowel rejection. Transplantation Proceedings 1997; 29: 1811-2.

25. Calne RY, Friend PJ, Middleton S, Jamieson NV, Watson CJE, Soin AS, Chavez-Cartaya R. Intestinal transplant between two identical triplets. The Lancet 1997; 350: 1077-8.

26. Soin AS, Friend PJ. Recent developments in transplantation of the small intestine. Br Med Bull. 1997;53(4):789-97.

27. Fujimoto Y, Soin AS, Tanaka K. Cadaveric Organ Transplantation in Japan – the past, the present and the future. National Medical Journal of India March-April 1998; 11(2): 89-91.

28. Butler A, Soin AS, Friend P et al. Intestinal isograft: functional recovery in absence of rejection, infection and immunosuppression. Transplantation Proceedings 1998; 30.

29. Soin AS, Nundy S, Acharya SK, Mathur M, Sahni P. Congestive gastropathy in non-cirrhotic portal hypertension: changes after decompressive shunt surgery. Journal of Clinical Gastroenterology 1998; 26: 64-8.

30. Soin AS, Metcalfe SM, Friend PJ. Depletion of peripheral blood lymphocytes using monoclonal antibodies for transplant tolerance: tip of the iceberg? Transplantation Proceedings 1998; 30: 2572.

31. Soin AS, Watson CJE, Friend PJ et al. Intestinal chronic rejection presenting with encephalopathy. Transplantation Proceedings 1998; 30.

32. Evans PC, Soin AS, Wreghitt TG, Alexander GJM. Qualitative and semi-quantitative polymerase chain reaction testing for Cytomegalovirus DNA in serum allows prediction of CMV related disease in liver transplant recipients. Journal of Clinical Pathology 1998; 51(12): 914-21.

33. Sibal A, Soin AS, Rajasekar MR. Liver transplantation in the developing world. Indian J Pediatr 1999;66(1 Suppl):S120-3.

34. Soin AS, Rajasekar MR. Laparoscopic Donor Nephrectomy – a major advance in kidney transplantation. Transplant Trends 1999; 4: 1-2.

35. Soin AS, Rajasekar MR, Rajakumari DV et al. Experience with laparoscopic donor nephrectomy in India: is the open approach justified any longer? Transplant Proc 2000 Nov; 32(7):1585.

37. Evans PC, Soin AS, Wreghitt TG, Taylor, CJ, Wight D, Alexander GJ. An association between cytomegalovirus infection and chronic rejection after liver transplantation. Transplantation 2000 Jan 15;69(1):30-5.

38. Soin AS, Rajasekar MR, Sibal A, Rajakumari V. Living related liver transplantation in children: first report of three successful cases in India. Indian Journal of Pediatric Surgery 2000 (in press).

39. Soin AS, Rajasekar MR, Rajakumari DV, Mishra A. Jasuja S. The success of laparoscopic donor nephrectomy: Is the open approach justified? Transplant Proc 2001; 33:1997-8

40. Poonacha P, Sibal A, Soin AS, Rajasekar MR, Rajakumari DV. India’s first successful pediatric liver transplant. Indian Pediatr 2001; 38: 287-91

41. Soin AS, Rajasekar MR, Rajakumari DV, Sibal A. Single-centre experience of liver transplantation from India’s first liver transplant programme. Indian Journal of Gastroenterology 2001 (INASL suppl).

42. Rajasekar MR, Soin AS, Rajakumari DV. Successful adult-to-adult living donor right lobe transplantation in India. Indian Journal of Gastroenterology 2001 (INASL suppl).

43. Sibal A, Soin AS, Rajasekar MR, Rajakumari DV, Poonacha P. Pediatric liver transplantation: experience from a single centre and the lessons learnt.. Indian Journal of Gastroenterology 2001 (INASL suppl).

44. Singhal D, Vasdev N, Gupta S, Soin AS, Nayak NC, Nundy S. Fibrolamellar hepatocellular carcinoma- Not a rare tumor in India and a possible new marker. Journal of Gastroenterology and Hepatology 2002;17(Suppl.):A1051:67.

45. Gupta S, Soin AS, Singhal D, Somashekar U, Verma V, Kumar M, Nundy S. Mesocaval shunt using external iliac vein interposition graft as an alternative to TIPSS. Journal of Gastroenterology and Hepatology 2002;17(Suppl.):A1054:72.

46. Soin AS, Gupta S, Jain P, Sewkani A, Singhal D, Verma V, Somashekar U, Kumar M, Nundy S. Middle hepatic vein outflow reconstruction in right lobe liver transplantation- Experience of two cases. Journal of Gastroenterology and Hepatology 2002;17(Suppl.):A1034:24.

47. Gupta S, Soin AS, Jain P, Sewkani A, Singhal D, Somashekar U, Verma V, Kumar M, Nundy S, Singh S, Buxi TBX. Utility of CT angiography in defining segment 5 and 8 venous tributaries in adult - adult living donor liver transplantation: An Indian series. Journal of Gastroenterology and Hepatology 2002;17(Suppl.):A1034:25.

48. Soin AS, Gupta S, Jain P, Singh A, Khullar D, Gupta A, Bhalla A, Rana DS. Graft function and recepient complications after lapoaroscopic donor nephrectomy. Transplantation 2002;74(4)S:674

49. Soin AS. Invited editorial on Liver Transplantation entitled “Liver Sutra” in Hindustan Times, 20 August 2003

50. Soin AS. Ethical dilemmas in living donor liver transplantation (Editorial). Issues Med Ethics 2003; 11:104-5.

51. Soin AS. Summary of proceedings of the First National Consensus Symposium on Liver Transplantation and Cadaveric Organ Donation. Indian Transplant, October 2003.

52. Soin AS, Gupta S, Saigal S, Nundy S. Adult to adult living donor left lobe liver transplantation: does size really matter? Journal of Gastroenterology and Hepatology 2004; 19 [S]: A 846.

53. Vij V, Soin AS, Gupta S et al. POSSUM as a predictor of mortality in liver resections. Journal of Gastroenterology and Hepatology 2004; 19 [S]: A 844.

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