Some diseases destroy healthy liver cells or replace them with scarred (fibrous)
Tissues causing loss of liver function. When a large part of the liver is scarred it is called cirrhosis. Cirrhotic liver loses its capacity to re grew or regenerate causing loss of liver function; this is often progressive and irreversible. Cirrhosis cannot be treated or reversed with any medicines.
Liver has the capacity to regenerate .event if 70% of liver damaged, the remaining liver can provide adequate organ function.However, damage beyond this causes loss of liver function or organ failure,called End Stage Liver Disease(ESLD).
Although cirrhosis cannot be reversed,if diagnosed at an early stage,treating its cause such as viral or autoimmune hepatitis or abstinence from alcohol can halt its progression.
Liver transplantation is universally the standard of care for treatment of end stage chronic liver disease or cirrhosis and is a life saving operation for patients with acute liver failure. Donated liver can from a living donor or a deceased (brain dead, cadaveric) donor. This article to make patients familiar with benefits and risks of liver transplantation
Patients with cirrhosis feel normal until ESLD sets in, when following signs and symptoms may develop:
1. Yellowness of skin and white portion of the eyes or passing dark yellow urine(jaundice)
2. Swollen abdomen- fluid build –up in abdmon(ascites)
3. Excessive sleepiness,inability to sleep, becoming forgetful,drowsy or confused(encephalopathy),due to build up ammonia and toxins
4. Throwing up blood(blood vomiting) ,passing tarry black stools or fresh red bleeding in stool due to bleeding in intestines
5. passing light or clay colored stools
6. Easy or texcessive bruising or bleeding even from simple wounds
7. Constant & severe itching (pruritus) all over the body
8. Feeling tried or weak
9. Loss of appetite
10. Unintentional weight loss
11. Loss muscle mass
12. Swelling (edema) of hands and feet.